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29:36
YouTube
Kartik Nakhate
Alzheimer's disease and its treatment (Donepezil, Memantine)
After synthesis, APP is inserted into the neuronal membrane. Thereafter, some of the APP is broken into several functional fragments by a set of dedicated proteases, termed secretases. Sequential cleavage of APP by alpha- and gamma-secretase produces non-toxic fragments. However, in the case of AD, either due to over-expression of APP formation ...
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