Meanwhile, whispers emerged throughout pockets of 2025 suggesting that quarterback Kyler Murray could be facing a make-or-break season regarding his Arizona tenure. He signed a five-year contract extension reportedly worth $230.5M with $160M guaranteed in the summer of 2022, but still has zero playoff wins on his career resume.

The Arizona Cardinals starters, including Kyler Murray, will play in the preseason opener against the Chiefs. That marks a change from previous years.

It has been a question with Jonathan Gannon teams since he arrived and for the first time we will see the Arizona Cardinals roll out the starters in the preseason. So, what can we expect?