Long-Term Side Effects of Sertraline (Zoloft) Sertraline has been used since the 1990s by tens of millions of people, and in that time there have been no established side effects specific to long ...

Zoloft works by increasing serotonin levels, which can cause side effects such as difficulty with climaxing and ED. It may not be the SSRI with the worst intimate side effects, though.

(Zoloft is not prescribed for children under 6 years.) Though this side effect was rare in Zoloft studies, the risk is highest in the first few months of treatment or following a dosage change.