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Drug Interactions: CNS Depressants: Clonidine may potentiate the CNS-depressive effects of alcohol, barbiturates, or other sedating drugs. Avoid concomitant use of CNS depressants with ONYDA XR.

U.S. FDA Approves Tris Pharma's ONYDA XR (clonidine hydrochloride) Extended-Release Oral Suspension, the First Liquid Non-Stimulant ADHD Medication ...

While clonidine can effectively manage withdrawal, a 2016 review of 26 studies notes that other medications, such as methadone or lofexidine, may have fewer side effects (more on this later).

Please refer to the full Prescribing Information for Clonidine Hydrochloride Extended-Release Tablets here. You can also call 1-888-650-3789 to obtain a copy of the full Prescribing Information.