Further, thiazide diuretic initiators with hyponatremia had 95% and 41% increased risks of hip fracture and ataxia, respectively, compared with the control group.

Initiating treatment with thiazide diuretics was linked to increased incidences of low blood sodium below 130 mmol/L, also known as hyponatremia, compared with non-thiazide antihypertensive drugs ...

Patients who develop early hyponatremia after starting thiazide diuretics have a higher mortality risk than those with normal sodium levels, according to retrospective study data. “Hyponatremia ...

Of these, 718 used thiazides at baseline and 2,738 started on thiazide therapy during follow-up. Hyponatremia developed in 522 subjects, of whom 32.4% were exposed to thiazide diuretics at the ...

Thiazide diuretics can be given at the same time as a loop diuretic when the two drugs are given by the oral route. Unfortunately, intravenous metolazone is not available.

Diabetes affected 27.1%. Mean age was 63.3 years. Half of the veterans initiated diuretics, of whom 77.4%, 22.5%, and 0.1% used thiazide, loop, and potassium-sparing diuretic users, respectively.

By component, the diuretic group had a significant 23%, 20%, and 16% decreased risk for renal replacement therapy, a 40% or greater decline in eGFR from baseline, and an eGFR less than 15 mL/min/1 ...

Thiazide, a popular diuretic for lowering high blood pressure, may not excrete salt as expected in patients with congestive heart failure and or dehydration and should be taken with caution, say ...

A common diuretic wasn't much help for staving off recurrent kidney stones, the NOSTONE trial showed. Over a median follow-up of 2.9 years, symptomatic or radiologic recurrence of kidney stones ...

Leitzmann MF et al. (2005) Thiazide diuretics and the risk of gallbladder disease requiring surgery in women. Arch Intern Med 165: 567–573 ...