In severe cases, a doctor may prescribe oral corticosteroids, such as prednisone, to treat poison ivy rash. These medications may provide rapid and steady relief from symptoms. Poison ivy rash can ...

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So medicines like prednisone can take you if you're baseline -- or if you're depressed -- and cause you to cycle into a mood swing. So you have to be very careful.

Doctors may prescribe prednisone for severe poison ivy reactions. The medication works by reducing the body’s immune response, which helps decrease the severe itching associated with the rash.