Three giants dominate the pharmaceutical supply chain The US drug distribution market is effectively an oligopoly. McKesson, Cencora, and Cardinal Health make up over 90% of the market by revenue.

References 1. Kotis D, Scimeca F, Reff M, et al. Beyond limits: Rethinking drug distribution to drive patient-centered care. Presented at: AXS25; April 30, 2025; Las Vegas, NV. 2.

The US drug distribution market is effectively an oligopoly. The Big Three—McKesson MCK, Cencora COR, and Cardinal Health CAH —make up over 90% of the market by revenue.